Tuesday, August 6, 2019

Cat In The Rain Essay Example for Free

Cat In The Rain Essay From the literary analysis I wrote, I want my readers to be able to read and understand the special relationship of the husband and wife in Ernest Hemmingway’s â€Å"Cat in the Rain.† Some critics believed that the cat representing the American wife’s desire for a child. From the first time we read Hemingway’s short story, I immediately jumped to conclusions such as the couple did not really like each other or maybe they just had a barrier in the relationship. I discovered from other critics online and through other members of the class, that I was not the only one who thought so. It was not very difficult to write the second paragraph of this paper. Many parts of the story and pieces from the articles had lots to say about the American wife and her barrier from her husban d. The paragraph about George was more difficult for me because for most of the story, he remained in the room reading throughout the story. By writing an annotation and a literary analysis over the same Hemingway story helped me to see the differences between them and how to critically analyze literature. I did struggle with quoting and referencing the articles that I drew information from, but I felt like I did my best on the writing portion of the paper. I didn’t learn much quite as much in my Comp 1 class, but I have been able to take and learn a lot from this class. Literature and writing essays has never been my strong area, but I have been able to appreciate learning what we have so far!

Monday, August 5, 2019

Current Status of Gene Therapy Research

Current Status of Gene Therapy Research Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, its the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is a technique for correcting defective genes responsible for disease development. Researchers may use one of several approaches for correcting faulty genes: A normal gene may be inserted into a nonspecific location within the genome to replace a nonfunctional gene. This approach is most common. An abnormal gene could be swapped for a normal gene through homologous recombination. The abnormal gene could be repaired through selective reverse mutation, which returns the gene to its normal function. The regulation (the degree to which a gene is turned on or off) of a particular gene could be altered. How does gene therapy work? In most gene therapy studies, a normal gene is inserted into the genome to replace an abnormal, disease-causing gene. A carrier molecule called a vector must be used to deliver the therapeutic gene to the patients target cells. Currently, the most common vector is a virus that has been genetically altered to carry normal human DNA. Viruses have evolved a way of encapsulating and delivering their genes to human cells in a pathogenic manner. Scientists have tried to take advantage of this capability and manipulate the virus genome to remove disease-causing genes and insert therapeutic genes. Target cells such as the patients liver or lung cells are infected with the viral vector. The vector then unloads its genetic material containing the therapeutic human gene into the target cell. The generation of a functional protein product from the therapeutic gene restores the target cell to a normal state. See adiagram  depicting this process. Some of the different types of viruses used as gene therapy vectors: Retroviruses   A class of viruses that can create double-stranded DNA copies of their RNA genomes. These copies of its genome can be integrated into the chromosomes of host cells. Human immunodeficiency virus (HIV) is a retrovirus. Adenoviruses   A class of viruses with double-stranded DNA genomes that cause respiratory, intestinal, and eye infections in humans. The virus that causes the common cold is an adenovirus. Adeno-associated viruses   A class of small, single-stranded DNA viruses that can insert their genetic material at a specific site on chromosome 19. Herpes simplex viruses   A class of double-stranded DNA viruses that infect a particular cell type, neurons. Herpes simplex virus type 1 is a common human pathogen that causes cold sores. Besides virus-mediated gene-delivery systems, there are several nonviral options for gene delivery. The simplest method is the direct introduction of therapeutic DNA into target cells. This approach is limited in its application because it can be used only with certain tissues and requires large amounts of DNA. Another nonviral approach involves the creation of an artificial lipid sphere with an aqueous core. This liposome, which carries the therapeutic DNA, is capable of passing the DNA through the target cells membrane. Therapeutic DNA also can get inside target cells by chemically linking the DNA to a molecule that will bind to special cell receptors. Once bound to these receptors, the therapeutic DNA constructs are engulfed by the cell membrane and passed into the interior of the target cell. This delivery system tends to be less effective than other options. Researchers also are experimenting with introducing a 47th (artificial human) chromosome into target cells. This chromosome would exist autonomously alongside the standard 46 not affecting their workings or causing any mutations. It would be a large vector capable of carrying substantial amounts of genetic code, and scientists anticipate that, because of its construction and autonomy, the bodys immune systems would not attack it. A problem with this potential method is the difficulty in delivering such a large molecule to the nucleus of a target cell. What is the current status of gene therapy research? The Food and Drug Administration (FDA) has not yet approved any human gene therapy product for sale. Current gene therapy is experimental and has not proven very successful in clinical trials. Little progress has been made since the first gene therapy clinical trial began in 1990. In 1999, gene therapy suffered a major setback with the death of 18-year-old Jesse Gelsinger. Jesse was participating in a gene therapy trial for ornithine transcarboxylase deficiency (OTCD). He died from multiple organ failures 4 days after starting the treatment. His death is believed to have been triggered by a severe immune response to the adenovirus carrier. Another major blow came in January 2003, when the FDA placed a temporary halt on all gene therapy trials using retroviral vectors in blood stem cells. FDA took this action after it learned that a second child treated in a French gene therapy trial had developed a leukemia-like condition. Both this child and another who had developed a similar condition in August 2002 had been successfully treated by gene therapy for X-linked severe combined immunodeficiency disease (X-SCID), also known as bubble baby syndrome. FDAs Biological Response Modifiers Advisory Committee (BRMAC) met at the end of February 2003 to discuss possible measures that could allow a number of retroviral gene therapy trials for treatment of life-threatening diseases to proceed with appropriate safeguards. In April of 2003 the FDA eased the ban on gene therapy trials using retroviral vectors in blood stem cells. What factors have kept gene therapy from becoming an effective treatment for genetic disease? Short-lived nature of gene therapy   Before gene therapy can become a permanent cure for any condition, the therapeutic DNA introduced into target cells must remain functional and the cells containing the therapeutic DNA must be long-lived and stable. Problems with integrating therapeutic DNA into the genome and the rapidly dividing nature of many cells prevent gene therapy from achieving any long-term benefits. Patients will have to undergo multiple rounds of gene therapy. Immune response   Anytime a foreign object is introduced into human tissues, the immune system is designed to attack the invader. The risk of stimulating the immune system in a way that reduces gene therapy effectiveness is always a potential risk. Furthermore, the immune systems enhanced response to invaders it has seen before makes it difficult for gene therapy to be repeated in patients. Problems with viral vectors   Viruses, while the carrier of choice in most gene therapy studies, present a variety of potential problems to the patient toxicity, immune and inflammatory responses, and gene control and targeting issues. In addition, there is always the fear that the viral vector, once inside the patient, may recover its ability to cause disease. Multigene disorders   Conditions or disorders that arise from mutations in a single gene are the best candidates for gene therapy. Unfortunately, some the most commonly occurring disorders, such as heart disease, high blood pressure, Alzheimers disease, arthritis, and diabetes, are caused by the combined effects of variations in many genes. Multigene or multifactorial disorders such as these would be especially difficult to treat effectively using gene therapy. For more information on different types of genetic disease, see  Genetic Disease Information. What are some recent developments in gene therapy research? Nanotechnology + gene therapy yields treatment to torpedo cancer. March, 2009. The School of Pharmacy in London is testing a treatment in mice, which delivers genes wrapped in nanoparticles to cancer cells to target and destroy hard-to-reach cancer cells. Read  BBC article. Results of worlds first gene therapy for inherited blindness show sight improvement. 28 April 2008. UK researchers from the UCL Institute of Ophthalmology and Moorfields Eye Hospital NIHR Biomedical Research Centre have announced results from the worlds first clinical trial to test a revolutionary gene therapy treatment for a type of inherited blindness. The results, published today in the New England Journal of Medicine, show that the experimental treatment is safe and can improve sight. The findings are a landmark for gene therapy technology and could have a significant impact on future treatments for eye disease. Read  Press Release. Previous information on this trial (May 1, 2007): A team of British doctors from Moorfields Eye Hospital and University College in London conduct first human gene therapy trials to treat Lebers congenital amaurosis, a type of inherited childhood blindness caused by a single abnormal gene. The procedure has already been successful at restoring vision for dogs. This is the first trial to use gene therapy in an operation to treat blindness in humans. See  Doctors Test Gene Therapy to Treat Blindness  at www.reuters.com.   A combination of two tumor suppressing genes delivered in lipid-based nanoparticles drastically reduces the number and size of human lung cancer tumors in mice during trials conducted by researchers from The University of Texas M. D. Anderson Cancer Center and the University of Texas Southwestern Medical Center. See  Dual Gene Therapy Suppresses Lung Cancer in Preclinical Test  at www.newswise.com (January 11, 2007). Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, successfully reengineer immune cells, called lymphocytes, to target and attack cancer cells in patients with advanced metastatic melanoma. This is the first time that gene therapy is used to successfully treat cancer in humans. See  New Method of Gene Therapy Alters Immune Cells for Treatment of Advanced Melanoma  at www.cancer.gov (August 30, 2006).   Gene therapy is effectively used to treat two adult patients for a disease affecting nonlymphocytic white blood cells called myeloid cells. Myeloid disorders are common and include a variety of bone marrow failure syndromes, such as acute myeloid leukemia. The study is the first to show that gene therapy can cure diseases of the myeloid system. See  Gene Therapy Appears to Cure Myeloid Blood Diseases In Groundbreaking International Studyat www.cincinnatichildrens.org (March 31, 2006).   Gene Therapy cures deafness in guinea pigs. Each animal had been deafened by destruction of the hair cells in the cochlea that translate sound vibrations into nerve signals. A gene, called  Atoh1,  which stimulates the hair cells growth, was delivered to the cochlea by an adenovirus. The genes triggered re-growth of the hair cells and many of the animals regained up to 80% of their original hearing thresholds. This study, which many pave the way to human trials of the gene, is the first to show that gene therapy can repair deafness in animals. See  Gene Therapy is First Deafness Cure  at NewScientist.com (February 11, 2005). University of California, Los Angeles, research team gets genes into the brain using liposomes coated in a polymer call polyethylene glycol (PEG). The transfer of genes into the brain is a significant achievement because viral vectors are too big to get across the blood-brain barrier. This method has potential for treating Parkinsons disease. See  Undercover Genes Slip into the Brain  at NewScientist.com (March 20, 2003). RNA interference or gene silencing may be a new way to treat Huntingtons. Short pieces of double-stranded RNA (short, interfering RNAs or siRNAs) are used by cells to degrade RNA of a particular sequence. If a siRNA is designed to match the RNA copied from a faulty gene, then the abnormal protein product of that gene will not be produced. See  Gene Therapy May Switch off Huntingtons  at NewScientist.com (March 13, 2003). New gene therapy approach repairs errors in messenger RNA derived from defective genes. Technique has potential to treat the blood disorder thalassaemia, cystic fibrosis, and some cancers. See  Subtle Gene Therapy Tackles Blood Disorder  at NewScientist.com (October 11, 2002). Gene therapy for treating children with X-SCID (sever combined immunodeficiency) or the bubble boy disease is stopped in France when the treatment causes leukemia in one of the patients. See  Miracle Gene Therapy Trial Halted  at NewScientist.com (October 3, 2002). Researchers at Case Western Reserve University and Copernicus Therapeutics are able to create tiny liposomes 25 nanometers across that can carry therapeutic DNA through pores in the nuclear membrane. See  DNA Nanoballs Boost Gene Therapy  at NewScientist.com (May 12, 2002).   Sickle cell is successfully treated in mice. See  Murine Gene Therapy Corrects Symptoms of Sickle Cell Disease  from March 18, 2002, issue of  The Scientist. What are some of the ethical considerations for using gene therapy? Some Questions to Consider What is normal and what is a disability or disorder, and who decides?   Are disabilities diseases? Do they need to be cured or prevented?   Does searching for a cure demean the lives of individuals presently affected by disabilities?   Is somatic gene therapy (which is done in the adult cells of persons known to have the disease) more or less ethical than germline gene therapy (which is done in egg and sperm cells and prevents the trait from being passed on to further generations)? In cases of somatic gene therapy, the procedure may have to be repeated in future generations.   Preliminary attempts at gene therapy are exorbitantly expensive. Who will have access to these therapies? Who will pay for their use?

Sunday, August 4, 2019

Thomas Paine :: essays research papers

Author During the 1770s Thomas Paine was a political philosopher and writer. He encouraged people to fight for American independence from Britain. He is one of the more creative figures of his period. Paine talked about American revolutionary ideas with his 1776 writing, Common Sense. In the writing, Paine made a point that Great Britain was trying to corrupt the American colonies and that they contributed nothing to America’s well being. Summary Paine published this 50-page story, Common Sense, on January 10, 1776. In this essay, it said that the American colonies had received no advantage from Great Britain, which was trying to corrupt them, and that every thought of "common sense" called for the colonies to become independent and to establish a republican government of their own. The story criticized Great Britain for its corruption toward the colonies as a whole. Argument Thomas Paine’s "Common Sense" played a large part in the separation from England. Paine thought the colonies had the right to revolt against a government that imposed taxes on them but didn’t give them the right to represent them in the current government. Thomas believed there was no reason for the Colonies to stay dependent on England. He had an awesome way of persuading people to take action through his writing. Paine says that sooner or later independence from England must come, because America had lost touch with the mother country. All the arguments for separation of England are based on nothing more than the facts and arguments. Paine saw the government as a possessed demon that could only become good when it was represented truthfully and changed by elections. He uses argumentation, in that the writer presents and logically supports a particular view or opinion. Paine uses motivation by which people’s values, desires, wishes, and needs are m entioned. His writing’s brought courage in a time of need to people who wanted to become independent. At the time that Paine wrote "Common Sense" the colonies were still thinking about declaring their independence from Great Britain. Some people told their leaders in the Continental Congress to act against separation from the mother country, which made thousands of colonists undecided about what to do. Today’s Government of the United States is similar to that of England in the 1770’s. They are similar in ways such as taxes and basic ways of living. Both control our rate of taxes without our say in the matter.

Saturday, August 3, 2019

The Powerful Message of Jubilate Agno :: Jubilate Agno Essays

The Powerful Message of Jubilate Agno        Ã‚  Ã‚   Jubilate Agno is Christopher Smart's poem which illustrates at first glance a testament to his religious obsession and his deteriorated mental state. The other side of this poem shows a man trying to keep his sanity in an insane place. William Stead sees the work as "a spiritual diary of his thoughts, memories, and prayers, during the darkest years of his life" (Stead 17). Jubilate Agno focuses on God with daily occurrences weaving their way into the poem. Smart's work "reflects what was . . . his life work: the praise of God through poetry" (Anderson 54). Smart writes about what he knows from the Bible to animals to the alphabet; most contain God themes [?]. In his tribute to his cat, Jeoffry, Smart shows the cat's particular connection to God, and how Jeoffry is the ideal servant of God. Is an insane Smart writing about an imaginary cat's servitude to God? Or is the intellectual Smart merely paralleling human life to cat life to show how each of us can ser ve God?    Jeoffry became more than a pet to Smart in the years of his confinement. Dr. Sherbo contends that "he had a cat, a real one, not the product of his distressed imagination" (qtd. in Dearnley 155). Smart, being particularly religious, felt that his companion was a good illustration of serving God in his ways. Jeoffry is aware of God, "For he knows that God is his Saviour" (134) just as we should. Smart refers to Jeoffry working for God, "for when his day's work is done his business more properly begins. / For he keeps the Lord's watch in the night against the adversary" (Smart 133). Jeoffry strives to serve God so much that after each full day of activities he can still be a servant to God. With the detailed descriptions of Jeoffry's daily routines, Smart sees the holy connection in them. "For at the first glance of the glory of God in the East he worships in his way. / For this is done by wreathing his body seven times round with elegant quickness" (131). A morning stretch for a feline symbolizes a morning prayer for a person.

J. D. Salinger’s The Catcher in the Rye Essay -- Salinger Catcher Rye

J. D. Salinger’s The Catcher in the Rye "There’s far more to the censorship issue than a ban on sex and four-letter words. I sometimes think that those of us who need to be the most clearheaded about these matters are planting the very trees that obscure our view of the forest," says Dorothy Briley. According to Briley, a vast amount more is needed than simply vulgar language and suggestive material to censor a novel. But this is the very reason why J. D. Salinger’s The Catcher in the Rye is frequently being banned from high schools. To the teenage readers, who are at the transition from childhood to adulthood, the protagonist of The Catcher in the Rye, Holden Caulfield, who has not quite reached the brink of manhood, becomes the reader’s hero. The adolescent mind that Salinger portrays so accurately in his novel is one with which most teenagers and readers, at one time or another, could identify. The Catcher in the Rye also contains universal themes that, for teenagers about to shift into adulthood, help young adults better understand the world and other people. Although it does contain abusive language and sexual connotations, The Catcher in the Rye by J. D. Salinger should not be censored in high schools because it provides insightful information and relevance to the life of young adults through its realistic situations and themes of acceptance and materialism. The reader can relate to the realistic situations, such as the scene at the Lunts play, present in the ...

Friday, August 2, 2019

Stalin – History

How far was Stalin’s victory in the power struggle between 1924 and 1929 the result of the popularity of his policies? Even though Stalin’s victory in the power struggle was partly due to his popular policies, it was not just this that allowed Stalin also because of the mistakes made by other rivals and factors that played into his hands. For example Trotsky was a former menshevik which helped Stalin accuse him of not been a true Bolshevik. There are many reasons that suggest Stalin’s victory in the power struggle was because his popular policies.For example Stalin’s popular policy of Socialism in one country put the needs of the USSR first, this was particularly popular because the conditions for the majority of the Russian people was unthinkable as extreme poverty was common for the average Russian in the the early 20th Century. It was a lot more popular than Trotsky's idea of World revolution, which would have seen many of the resources owned by the USS R sent abroad to try spread the Communist revolution abroad in other countries. Stalin developed his idea in Socialism in one Country because he did not like Trotsky.Stalin recognised that Trotsky’s policy was over optimistic and unpopular. The First World War and the civil war had destroyed the Russian economy and Stalin’s policy showed faith in the soviet people, almost portraying that Stalin believed in the Russian people. Stalin portrayed the Worldwide revolution as a policy that put the needs of other countries before those of the Russian people. Trostsky’s Jewish background marked him as a disloyal outsider among many party members anyway, and his international policy only seemed to confirm that he was not loyal to the people of Russia.It was not just his popular policies that saw Stalin replace Lenin as the leader of the USSR. It was also partly due to the mistakes and weaknesses made by the other leading Bolsheviks such as Trotsky. Trotsky was seen as to o powerful because he was the leader of the 5 million strong red army, he was known as the Red Napoleon. Trotsky was also Jewish, even though he himself believed that this reason would stop him from becoming the next leader, many argue that this was not such a big problem.However he was an ex menshevik which allowed Stalin to question his belief in Bolshevism, it was this fear that Trotsky was too powerful that led to kamenev and Zinoviev to side with Stalin. His popular policies were key to Stalin becoming the next leader of the USSR. Stalin’s commitment to the NEP until 1927 allowed him to defeat the united opposition of Trotsky, Zinoviev, and Kamenev. After the fall of Trotsky Zinoviev and Kamenev realised that Stalin was now the most powerful figure in the party and they began to speak out against the NEP.This was not only an attack on Stalin but an attack on Bukharin resulting in the two uniting. The NEP was particularly popular because it was following the line of Lenin and more than anything it seemed to be working as the Russian economy recovered in the mid 1920's. However Stalin was victorious in the power struggle not just because his policies were popular but because he had a great deal of luck. The two main pieces of luck that Stalin had was the ban on factionalism introduced by Lenin before his death and the appointment of Stalin as general secretary in 1922.Originally when Stalin was first appointed as General Secretary many Bolsheviks didn't realise the potential power which this now gave Stalin,one Menshevik described Stalin as the ‘grey blur'. However this gave Stalin power that nobody could have anticipated, it allowed for Stalin to appoint the regional secretaries, meaning that Stalin was able to rebuild the party by selecting the people who he wanted into key posts. This meant that slowly the party was been built up of people which were supporters of Stalin. The second bit of luck which inevitably benefited Stalin was the Ban o n Factionalism which was introduced in 1921.This ‘Ban on Factionalism' meant that everybody within the party were not able to speak out against official party policies and if somebody did then they were accused of been a factionalist and therefore expelled from the party. This benefited Stalin greatly as he could use this to his advantage, anybody that publicly spooke out against one of the policies which he supported could be branded as a factionalist and not a supporter of Lenin and therefore be defeated in the struggle for power. It could be argued that Stalin's policies were the main reason as to why he was victorious in the power struggle, however it is important to remember hat Stalin was extremely pragmatic when it came to what he believed in, changing his mind and supporting particular policies when it suited him, so the real fundamental reason as to why Stalin was victorious in the power struggle was because Stalin unlike the other leading figure of the party played h is cards right and was clever when it came to who he sided with. It was his cunningness combined with the amount of luck which he had which led to him eventually becoming the next leader of Russia in 1928.

Thursday, August 1, 2019

Three Day Food Intake

Food Intake Three Days Food Intake Three Days Healthy eating is important to the human body. Healthy eating provides the body with nutrients and energy to help the body function properly. Nutrients provide the body energy to keep the brain cells active, the heart pumping, and the muscle flexible. Nutrients also help to build strong bones, enhance the circulatory system, and other bodily functions. Healthy dieting means to consume all food groups so the diet can have a variety of fruits, vegetables, grains, milk, meats, bean, and oils.Even when eating from all food groups individuals must eat in moderation controlling the fats, salts, and sugars to maintain a healthy diet (Richford, 2011). Upon enrolling in a Human Nutrition class the professor assigned an individual assignment to assess my eating habits through iprofile factoring my weight, height, age, meals, and daily activities. The assessment evaluates three days of eating breakfast, lunch, dinner, and snacks. The nutrients asses sed were the lipids, proteins, and carbohydrates to access my positives and negatives about healthy eating.I entered my daily intake for three days and what a discovery. I revealed that my protein intake was excellent 70%, my lipids were high by 11%, and my carbohydrates were 80% below the recommended DRI. The results shocked me because I am not a regular meat eater, but my protein intake was in excellent. The carbohydrates did surprise me at all because I love eating vegetables, sweets, and I consume very little to none to be honest. Because I am fully aware that I need to make a change to avoid further issues, here are some ways that I intend to improve my carbohydrates.First I will eat more vegetables consuming the recommended amount two cups per day, ensuring that the vegetables are different every week. Carbohydrates are the main energy source for cells and organs. The basic carbohydrate units are called monosaccharide’s, such as glucose, GA lactose, and fructose. Glucos e and glycogen are stored in the liver and when the body becomes. Carbohydrates help fuel the body and create sugar. Sugar causes the body to release insulin and stress hormones. Consuming too much carbohydrate leads to obesity, diabetes, and several more health problems.The groups of foods that are underrepresented in my diet are grains, fruits, milk, and vegetables. The groups of foods that are overrepresented are meat and beans and discretionary. I honestly do not have a good excuse as to why I did not consume the recommended number of servings for each of the food groups. I only have myself to blame and I believe that my reasoning is sad. I am busy with school and work, I like food. I eat what I want when I want it which is not healthy. Proteins are important for repair and tissue growth helps the body to make enzymes and hormones, as well as preserve lean muscle mass and is a source of energy.My daily protein recommendations 71 grams. Protein has many important functions in the body and is essential for growth and maintenance. Protein needs can easily be met by eating a variety of plant-based foods. Combining different protein sources in the same meal is not necessary. Sources of protein for vegetarians and vegans include beans, nuts, nut butters, peas, and soy products (tofu, tempeh, veggie burgers). Milk products and eggs are also good protein sources for lacto-ovo vegetarians. Iron sources for vegetarians include cereals, spinach, and kidney beans.Calcium is used for building bones and teeth and in maintaining bone strength. Sources of calcium for vegetarians and vegans include calcium-fortified soymilk, calcium-fortified breakfast cereals and orange juice, tofu made with calcium sulfate, and some dark-green leafy vegetables the amount of calcium that can be absorbed from these foods varies. Consuming enough plant foods to meet calcium needs may be unrealistic for many. Milk products are excellent calcium sources for lacto vegetarians. Dietary fiber is prominent in recommendations for prevention of both coronary heart disease and cancer.The National Cancer Institute gives primary emphasis to dietary fiber in its recommended food choices. A range of intake of 20 to 30 g/d is suggested for US adults. The National Heart, Lung, and Blood Institute, through its National Cholesterol Education Program, emphasize reduction in fat intake and compensatory energy replacement through the increased intake of other foods, including those with high fiber content. (Fiber Study,  2012). Not in sufficient protein intake may cause tissue injury and muscle wasting. Too many proteins chronically hard of kidneys, such as progression of renal failure, gout and cancer.Excessive intake Carbohydrates make high risk of blood sugar and are heart disease. Fiber intake in normal limits to prevents the high risk colon cancer. Not in sufficient amount cause colon disease and bowel syndrome. References Fiber study. (2012). Retrieved from http://circ. ahajourna ls. org/ My plate. (2012). Retrieved from http://www. myplate. gov Richford, (2011). nutrition study. Retrieved from http://nutritionstudy. com Gordon, M. , & Smith, A. M. (2011). Contemporary Nutrition (8th ed. ). New York, New York: Mc graw hill. Grosvenor, M. , & Smolin, L. (2012). Visualization nutrition: Everyday choices